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The concomitant utilization of DEMEROL Tablets or Oral Option and CYP3A4 or CYP2B6 inducers can decrease the plasma concentration of meperidine [see Clinical Pharmacology (12.3)], leading to lessened efficacy or onset of the withdrawal syndrome in patients who've made physical dependence to meperidine [see Warnings and Safety measures (five.

5.5 Neonatal Opioid Withdrawal Syndrome Usage of DEMEROL Tablets and Oral Solution for an extended period of time during pregnancy may end up in withdrawal from the neonate. Neonatal opioid withdrawal syndrome, as opposed to opioid withdrawal syndrome in Older people, might be lifestyle-threatening if not acknowledged and addressed, and necessitate

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